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Glade is a graphical GUI builder for the GTK toolkit. You can build up an interface, and connect predefined events to custom hooks (for instance, connecting the button-clicked event to "on_button_clicked"). Glade saves the interface as XML, which can then be loaded up by PyGTK.
Gnome is a desktop environment for Linux that uses the GTK toolkit. Glade was developed for the Gnome project, though Gnome is not required for Glade to run; only GTK is needed.
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