Sane - as jonaskoelker said, it all depends on what toolkit you're using for your graphical elements. Do some research on all the toolkits available, and you'll find that the best solution is PyQt if you don't want to write commercial apps (or if you do, and happen to have ~$1700 laying around), and wxPython otherwise. Personally I use wxPython in Python and Qt/KDE with C++.
There are some pretty good, explanatory wxPython tutorials available on the net. Ask Google (which actually yields quite good results, contrary to beliefs expressed in this thread)
