Originally Posted by titaniumdecoy

Trust me, you do not want to simulate Windows to run a Microsoft IDE. Even if you get it to launch, it will be very slow and crash often. You can, however, either install Windows on a partition of your hard drive and boot into it via Boot Camp (free), or use Parallels Desktop or VMware Fusion (both are around $80) to run Windows in a window without rebooting. All of these options require a copy of Windows (preferably XP); if you are a student you may be able to get it for free through the MSDNAA program at your school.

VB 2005 Express is not a .NET application, so you cannot use Mono to run it. In addition, Mono implements only a limited subset of Windows' .NET implementation so you would not be able to run it even if it were a .NET application.

You may be able to get it to work with Wine or Codeweavers. As I said, even if you do the result will probably not be what you expect. However, I may be wrong since I haven't tried it.